Canadian CBD oils have gained a lot of popularity in recent times. People are skeptical about them because of the effects associated with marijuana products. Opioids have also been used for long to relive pain. They are addictive though. What is the relationship between CBD oil and Opioids? Let’s explore each and find out.
The compounds in the cannabis plant are referred to as cannabinoids. CBD is one of the many compounds found in the cannabis plant.
Comparison Between CBD and Marijuana
Delta-9 tetrahydrocannabinol(THC) is the most active cannabinoid. Both THC and CBD are found in marijuana plants. THC is psychoactive while CBD is not. In the field of medicine, CBD has been found to possess a lot of medical benefits.
Mechanism OF Action
For the CBD to have an effect am effect in your body, it first needs to attach itself to specific receptors found in the body(people in Canada really know this). The two body receptors are CB1 and CB2.CB1 receptors are found all around the body but majority are in the brain. THC attaches to CB1 receptors. The CB1 receptors in the brain are involved in coordination and movement, emotions, pain among other functions.CB2 receptors are more concentrated in the immune system and they affect inflammation and pain.
Uses of CBD
CBD possess many benefits. They include:
• Contain anti-inflammatory properties.
• Naturally relieves pain.
• Research proves that CBD helps in quitting smoking and in drug withdrawals.
• Have a role in treating epilepsy and other mental disorders.
• Used as anti-cancer agent.
• Treatment of type 1 diabetes. Research shows that CBD may ease inflammation in the pancreas in type 1 diabetes.
• Research suggests that CBD cab be used to treat acne.
Side Effects of CBD
CBD is well tolerated across a wide range of doses. On the central nervous system, there have been no notable side effects. The significant side effects noted so far is:
• changes in weight and appetite have also been noted in some people.
Forms of CBD
Canadian CBD products come in different forms. CBD oils are the most common. They are taken orally by mixing them with beverages or food. Others are available as a thick paste. The paste is meant to be massaged in to the skin. The capsule form is also available for purchase. Other products are provided in spray forms and are meant to be administered sublingually.
Specific Dosage Forms of CBD Oil
-Chronic pain:2.5-20 mg by mouth for no more than 25days.
-Epilepsy: between 200-300mgfor up to 4 and half months.
-Movement disorders associated with Huntington’s disease:10mg/day for six weeks.
-Schizophrenia: between 40 and 1280mg/day for 4 weeks.
-Glaucoma: single dose of between 20 and 40mg sublingually.
New Canadian CBD
Our favorite Canadian site for CBD oil is cbdoilcanadahq.ca/. People in Toronto and Vancouver can buy online using a special discount code for their CBD oil.
They are chemical substances that bind to opioid receptors in the brain and body. They are associated with pain relief, reward and addictive behaviors. Opioids act on both central and peripheral nervous system. In the peripheral nervous, the effects of opioids in both the submucous plexus and myenteric plexus are responsible for powerful constipation. In tissues such as joint, opioids act to reduce inflammation. In Canada, many people are using CBD because of how popular it is.
From: The use of cannabinoids as anticancer agents – ScienceDirect ScienceDirect Elsevier RELX Group.
Examples of Opioids Drugs Compared To CBD
They are broadly categorized in to three groups namely:
• the agonists,
• partial/mixed agonists
• and the antagonists.
The available agonists include:
Examples of partial/mixed agonists are:
• and buprenorphine.
The antagonists are:
• and naltrexone
Mechanism of Action
Neuronal cell membranes have receptors that opioids act on in order to produce effects on neurons. The receptors are mu(m), delta(d) and kappa(k). They are one of the large family of receptors that possess 7 transmembrane-spanning domains of amino acids. Studies suggest that naturally-occurring opioid peptides, endorphin, interacts with m receptors and dynorphin with k receptors while enkephalins interact with d receptors. Compared to other opioids receptors, morphine has got higher affinity for m receptors. Naloxone is an opioid antagonist that inhibits all opioid receptors. When an opioid binds to the three receptors, an analgesic effect is experienced. The activation of m receptors produces more physical dependence as compared to the activation of the k receptors.
The CBD scene in Toronto is second to none.
Action Sites of Opioids on Neurons
Opioids act on the presynaptic nerve terminal and the postsynaptic neuron. In the presynaptic nerve terminal, the action of opioids is to inhibit neurotransmitter release which is a major effect in the nervous system. The postsynaptic actions of opioids are often inhibitory. The action affects many presynaptic sites on both inhibitory and excitatory neurons and causes postsynaptic effects as well. Therefore, the overall effect of opioids on the neuron is determined by the location and the density of the opioid receptors.
How Opioids Relieve Pain Compared To CBD
Analgesia is achieved by actions of opioids at several levels of the nervous system. The opioids cause the inhibition of the neurotransmitter release from the primary afferent terminals in the spinal cord and the activation of descending inhibitory controls in the midbrain. Opioids inhibit neurotransmitter release by a direct effect on Ca++ channels to reduce Ca++ entry, or indirectly by increasing the outward K+ current. This shortens repolarization time and the action potential’s duration.
Uses of Opioids(+ When Combined With CBD)
Opioids are primarily used medically for pain relief, anesthesia included. Other medical uses include:
• Diarrhea suppression.
• Cough suppression.
• Suppression of opioid induced constipation.
• Reversing opioid overdose.
• Replacement therapy for opioid disorder.
• Non-medically for their euphoric effects.
Side Effects of Opioids vs. CBD
The common side effects of opioid administration include:
• physical dependence,
• and respiratory depression.
The most common of the above side effects are constipation and nausea.
The less common side effects may include muscle rigidity, hyperalgesia, delayed gastric emptying, immunological and hormonal dysfunction.
Both CBD oils and opioids invention has played a positive role in the field of medicine. Despite the side effects, their benefits are overwhelming. A common medicinal benefit of both CBD oils and opioids is pain relieve. One of the most notable use of opioids is during procedures such as surgeries. They are used as analgesics. Due to legal issues, use of CBD oils is restricted in various parts of the world despite, their medicinal values and their few side effects. The main reason is due to the fact that CBD oils are extracted from cannabis sativa. Such restrictions make opioids use more common in most parts of the world as compared to CBD oils.